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KMID : 0374019840070040187
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Ewha Medical Journal
1984 Volume.7 No. 4 p.187 ~ p.190
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Blockade by naloxone and naltrexone of the TRH-induced Stimulation of Colonic Transit in the Rabbit
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Abstract
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Thyrotropin releasing hormore (TRH) administered intracerebroventricularly (i, c. v ) in microgram quantities to anesthetized rabbits, produces marked stimulation of colonic motility, transit and fluid accumulation.
These effects depend on an intact vagal system. Atropine blocks hypermotility, but not the increased intestinal transit and fluid accumulation. The latter effects are antagonized by antiserotonin compounds.
In this study we found that pretreatment of rabbits with naloxone ( 2.5 xg /kg or naltrexone (1.0x9/kg) attenuated or blocked the TRHinduced colonic transit and increase in luminal fluid, but not the hypermotilty.
t In this respect the narcotic antagonist effects resemble those produced by the antiserotonine compounds or opiate agonists.
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